منابع مشابه
Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS.
In search for novel markers for breast cancer, we aimed to identify and validate novel serum protein profiles specific for breast cancer, and assess the influence of clinical (subjects age) and pre-analytical (sample storage duration) variables on the constructed classifiers. To this end, sera of breast cancer patients (n=152) and healthy controls (n=129), randomly divided into a training and t...
متن کاملA proteomic (SELDI-TOF-MS) approach to estrogen agonist screening.
A small fish model and surface-enhanced laser desorption/ionization time-of-flight mass spectrometry were used to investigate plasma protein expression as a means to screen chemicals for estrogenic activity. Adult male sheepshead minnows (Cyprinodon variegatus) were placed into aquaria for seawater control, solvent control, and treatments of 17beta-estradiol (E2), methoxychlor (MXC), bisphenol-...
متن کاملAdvances in clinical cancer proteomics: SELDI-ToF-mass spectrometry and biomarker discovery.
For most cancers, survival rates depend on the early detection of the disease. So far, no biomarkers exist to cope with this difficult task. New proteomic technologies have brought the hope of discovering novel early cancer-specific biomarkers in complex biological samples and/or of the setting up of new clinically relevant test systems. Novel mass spectrometry-(MS) based technologies in partic...
متن کاملImportance of serum SELDI-TOF-MS analysis in the diagnosis of early lung cancer.
BACKGROUND Different methods of diagnosis have been found to be inefficient in terms of screening and early diagnosis of lung cancer. Cancer cells produce proteins whose serum levels may be elevated during the early stages of cancer development. Therefore, those proteins may be recognized as potential cancer markers. The aim of this study was to differentiate healthy individuals and lung cancer...
متن کاملReproducible Cancer Biomarker Discovery in SELDI-TOF MS Using Different Pre-Processing Algorithms
BACKGROUND There has been much interest in differentiating diseased and normal samples using biomarkers derived from mass spectrometry (MS) studies. However, biomarker identification for specific diseases has been hindered by irreproducibility. Specifically, a peak profile extracted from a dataset for biomarker identification depends on a data pre-processing algorithm. Until now, no widely acce...
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ژورنال
عنوان ژورنال: Clinical Proteomics
سال: 2009
ISSN: 1542-6416,1559-0275
DOI: 10.1007/s12014-009-9032-5